They can be used for long periods because they do not produce tolerance or dependence. In certain cases or occasions, the rheumatologist may consider it necessary to help paracetamol and non-steroidal anti-inflammatories with other analgesics such as tramadol or codeine.
Its main drawback is the damage they cause in the gastric mucosa, since they inhibit the synthesis of prostaglandins that protect the gastric mucosa Keto Viante. In prolonged treatments are associated with protectors of the gastric mucosa. They are administered orally, although there is also the possibility that they are prescribed topically, that is, on the skin covering the arthritic joint, in the form of gels, creams, ointments or nebulizers.
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